Clinical Chemistry and Laboratory Medicine

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Issue: Sep 2003

Clinical Chemistry and Laboratory Medicine
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Clinical Chemistry and Laboratory Medicine

ISSN (Print) 1434-6621

ISSN (Online) 1437-4331

DOI 10.1515/cclm.367

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Issue: Sep 2003

Volume 41, Number 9

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Carbonyl Stress and Diabetic Complications

Toshio Miyata,
Naoyoshi Ishikawa,
Charles van Ypersele de Strihou
Citation Information. Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 9, Pages 1150–1158, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.178, September 2003
Published Online: 01/06/2005

Abstract

Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation end-products (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of “carbonyl stress” in complicated diabetes and, finally, discuss therapeutic perspectives.

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http://dx.doi.org/10.1515/CCLM.2003.178

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